Scaffold attachment factor B1; Isoform 4 of Scaffold attachment factor B1;Scaffold attachment factor B1; Isoform 3 of Scaffold attachment factor B1

Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a ‘transcriptosomal’ complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}.

    Matrix Type

    • Plasma
    • Tissue/Cells

    Gene Symbol

    • SAFB

    UniProt ID

    • Q15424
    • Q15424-4

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