RUSD3

Mitochondrial mRNA pseudouridine synthase RPUSD3; Isoform 2 of Mitochondrial mRNA pseudouridine synthase RPUSD3; Isoform 6 of Mitochondrial mRNA pseudouridine synthase RPUSD3; Isoform 5 of Mitochondrial mRNA pseudouridine synthase RPUSD3

Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis (PubMed:27667664).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • RPUSD3

    UniProt ID

    • Q6P087
    • Q6P087-5
    • Q6P087-6
    Off-the-shelf

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