E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the ‘Lys-48’-linked polyubiquitination and degradation of TLR3 (PubMed:31076723). {ECO:0000269|PubMed:21610068, ECO:0000269|PubMed:31076723}.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • RNF170

UniProt ID

  • Q96K19

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