RHOU

Isoform 2 of Rho-related GTP-binding protein RhoU;Rho-related GTP-binding protein RhoU

Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • RHOU

    UniProt ID

    • Q7L0Q8

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