Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. {ECO:0000250|UniProtKB:Q8CHX7}.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • RFTN2

    UniProt ID

    • Q52LD8

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