Isoform 3 of Sodium/bile acid cotransporter 7; Isoform 1 of Sodium/bile acid cotransporter 7;Sodium/bile acid cotransporter 7

Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization (PubMed:29878199, PubMed:30082715). Also involved in the regulation of cellular calcium homeostasis (PubMed:30082715, PubMed:31191616). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • SLC10A7

    UniProt ID

    • Q0GE19
    • Q0GE19-3

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