MCAF1

Isoform 3 of Activating transcription factor 7-interacting protein 1;Activating transcription factor 7-interacting protein 1; Isoform 4 of Activating transcription factor 7-interacting protein 1; Isoform 2 of Activating transcription factor 7-interacting protein 1

Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 ‘Lys-9’ (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 ‘Lys-9’ trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • ATF7IP

    UniProt ID

    • Q6VMQ6
    • Q6VMQ6-4
    • Q6VMQ6-5

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