Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.

    Matrix Type

    • Plasma
    • Tissue/Cells

    Gene Symbol

    • DENND6A

    UniProt ID

    • Q8IWF6

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