Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • CUEDC2

    UniProt ID

    • Q9H467

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