CARL1

F-actin-uncapping protein LRRC16A;F-actin-uncapping protein LRRC16A; Isoform 2 of F-actin-uncapping protein LRRC16A

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667).

    Matrix Type

    • Plasma
    • Tissue/Cells

    Gene Symbol

    • CARMIL1

    UniProt ID

    • Q5VZK9

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