Biomarker Discovery Services: Discover More with Our Untargeted Approach

Sapient provides discovery as a service, leveraging our next-generation mass spectrometry approaches to probe small molecule chemistry at a rate that is unmatched for uncovering known and unknown metabolite biomarkers that associate with early disease, disease progression, and drug response.

Our nontargeted biomarker discovery services enable sponsors to rapidly identify, validate, and translate these novel biomarkers that can be utilized to accelerate their drug development programs, enrich clinical trials, and align patients, specific disease pathobiology, and specific, efficacious therapies. How do we do it?

Rapid liquid chromatography-mass spectrometry (rLC-MS) – our proprietary systems enable ultra high throughput, population-level biomarker discovery, capturing and measuring >11K small molecule biomarkers (both known and unknown) per sample, in <1 minute analytical cycle time.

Biocomputational integration – our expert team of data scientists apply statistical and machine learning tools to rapidly identify key biomarkers of interest, integrating our spectral data with other high dimensional data from preclinical models, genomics, proteomics, and clinical studies.

Human Biology Database – encompassing data from >100,000s of human biosamples for cross-validation of biomarkers in large, independent populations.

Discover why Sapient is the biomarker discovery CRO you want to partner with, and how we can work together to advance your drug programs, at any phase. Use the form to download our technical fact sheet or schedule a time to talk to our scientists here.