Resource Library
Application Notes
Articles
Brochures
Case Studies
Events
Infographics
Media
Papers
Podcasts
Press Releases
Videos
Webinars
Event
Join us at Biomarkers US 2023
October 12-13, 2023 | Hilton San Diego Bayfront | San Diego, CA…
Webinar
Dynamic Biomarkers for Deep Immune Phenotyping in Autoimmune Disease
October 5, 2023 | 12:00pm ET / 9:00am PT | Hosted by Oxford…
Media
The Future Is Now: Authority Magazine Interview with Sapient's Jeramie Watrous
“Out of graduate school, Dr. Mohit Jain (co-founder and CEO of Sapient, but a university professor at the time) approached…
Podcast
Futurati Podcast: Biomarkers and personalized medicine
“I would argue that for nearly every common disease, there are multiple forms of the disease that have been amalgamated…
Case Study
Discovery of a PD Biomarker to Predict Drug Response
The inherent heterogeneity in patient populations can often lead to variable drug response. We recently worked with a client who…
Press Release
Sapient’s High Complexity CLIA Laboratory Receives Accreditation from the College of American Pathologists (CAP)
August 2, 2023—San Diego, CA—Sapient, a biomarker discovery organization providing bespoke services for metabolomics and lipidomics data generation and analysis,…
Case Study
Discovery of PD-1 Pathway Biomarkers of Target Engagement
The PD-1 pathway has transformed the development of immunotherapies as a means to reawaken the immune…
Video
"Live from the Lab" at Sapient: On-Demand Virtual Lab Tour with Bruker
Watch the Livestream Recording | Presented by Bruker Watch the full recording of our recent lab…
Webinar
Nature Webinar | Beyond the genome: small-molecule biomarkers drive new advances in drug discovery
Now On Demand | Hosted by Nature Research…
Case Study
Discovery of an Early Diagnostic Biomarker for NASH
The incidence and prevalence of nonalcoholic fatty liver disease (NAFLD) continue to rise worldwide, estimated to affect over…
Podcast
VibeCast Podcast: Are Biomarkers the Future?
“Diagnostics have evolved tremendously. You could argue that the greatest benefit in human survival has come over the last 50…
Application Note
How metabolomics can enrich preclinical safety studies
Preclinical safety assessments play a pivotal role in mitigating risk to enhance drug development success. Early identification of toxicological effects…
Podcast
"Beyond Biotech" Podcast: A look at metabolite biomarkers with Sapient
“My hope is that in the very near future, in the next decade, an individual would go to a doctor’s…
Media
Biocom LifeLines Magazine Feature: "Illuminating unknowns in the dynamic interplay of genetics, environment, and disease"
Biocom California recently asked Sapient to contribute an article for its Lifelines Magazine, a forum sharing…
Video
Experts On... Biomarker Translation of Discoveries in Blood to Other Matrices
Having a multidisciplinary team gives us deep & diverse expertise to tap across our discovery endeavors.
Brochure
Sapient Fact Sheet
At Sapient, we believe that drugs can be developed much faster, cheaper, and more effectively through biomarker-driven drug discovery. Biomarkers…
Video
Small Molecule Biomarkers + Adaptive Clinical Trials: Optimize Dosing & Timing of Treatments
Adaptive clinical trial designs are an emerging approach that bring flexibility to traditional linear study designs by adding a…
Video
Experts On... Translating Biomarker Discoveries into Real-World Assays
Having a multidisciplinary team gives us deep & diverse expertise to tap across our discovery endeavors.
Brochure
Human Biology Database to Amplify Biomarker Discovery & Accelerate Validation
Greater discovery is enabled when data from individual disease and cohort studies can be homogenized and linked together, revealing biological…
Webinar
Timing is Everything: Biomarkers for Early Detection of Preclinical Toxicology Events
Now On Demand | Hosted by AAPS Small molecule biomarkers represent dynamic indicators of adverse effects…
Webinar
High-Throughput Biomarker Discovery for Clinical Trial Optimization
Now On Demand | Hosted by Oxford Global Advances in mass spectrometry resolution and sensitivity have enabled…
Paper
Reconstructing the landscape of gut microbial species across 29,000 diverse individuals
There is increasing evidence of the human gut microbiome’s link to health and disease. Exploring the composition and function of…
Brochure
Fact Sheet: Analytical Methods from Discovery to Diagnostic Development
There are tens of thousands of unmapped molecules circulating in human blood – thousands of which could represent robust biomarkers.
Podcast
"Lab to Launch" Podcast: Enabling the next generation of biomarker discovery with Dr. Mo Jain
If you look at the data, the best drugs work in only 50% of people. Sapient’s Founder and CEO, Dr. Mo…
Article
The Right Treatment, the Right Time: Biomarker-Guided Assessment of Clinical Trial Dynamics
Adaptive clinical trial designs seek to add flexibility to the fixed, linear “design-conduct-analyze” sequence of conventional…
Media
Technology Networks Feature: "Probing the Biomarker Landscape of Human Disease"
Technology Networks’ Anna MacDonald sat down with Sapient’s Dr. Mo Jain for this Industry Insights piece…
Video
Experts On... Delivering Value to Biopharma Sponsors
Having a multidisciplinary team gives us deep & diverse expertise to tap across our discovery endeavors.
Media
Sapient Featured in Biocompare Article, "Mass Spectrometry for Biomarker Discovery"
Biocompare recently spoke to a panel of experts, including Sapient’s CEO and Founder, Dr. Mo Jain, to get their takes…
Video
Experts On... The Impact of Chemical Discovery at Scale
Having a multidisciplinary team gives us deep & diverse expertise to tap across our discovery endeavors.
Webinar
The Clinical Trial Conundrum: Identifying Responders vs. Non-Responders
Now On Demand | Hosted by AAPS Will a patient respond or not respond to the…
Video
Experts On... Making Biomarker Discoveries Actionable
Having a multidisciplinary team gives us deep & diverse expertise to tap across our discovery endeavors.
Article
Mapping Metabolic Changes for Diabetes Prediction with Machine Learning
Understanding the risk factors that give rise to human disease is essential to early detection and development of effective treatments…
Video
Experts On... Multi-Omics Data Integration
Having a multidisciplinary team gives us deep & diverse expertise to tap across our discovery endeavors.
Infographic
Chemistries & Methods: How We Achieve Breadth and Depth in Chemical Discovery
There are tens of thousands of unknown molecules circulating in human blood – thousands of which could represent robust biomarkers.
Video
Experts On... Machine Learning in Biomarker Discovery
Having a multidisciplinary team gives us deep & diverse expertise to tap across our discovery endeavors.
Video
Experts On... Approaching Experimental Design
Having a multidisciplinary team gives us deep & diverse expertise to tap across our discovery endeavors.
Article
Thinking outside the brain to advance CNS drug development
CNS diseases can have a wide range of symptoms which can make them difficult to diagnose and treat based on…
Video
Experts On... Defining Biocomputational Approaches
Having a multidisciplinary team gives us deep & diverse expertise to tap across our discovery endeavors.
Brochure
Circulating Biomarker Discovery at Unprecedented Speed & Scale
Did you know that underlying risks for most common human diseases are not encoded in DNA sequence? Rather, they are…
Overview
Biomarker Discovery Services: Discover More with Our Untargeted Approach
Sapient provides discovery as a service, leveraging our next-generation mass spectrometry approaches to probe small molecule chemistry at a rate…
Overview
Untargeted Lipidomics Services for an Unprecedented Scale of Biomarker Discovery
Sapient leverages its next-generation mass spectrometry approaches to probe deeper into the human lipidome at a rate that is…
Webinar
Fierce Webinar: Population-Scale Circulating Biomarker Discovery to Accelerate Drug Development
Now On Demand | Hosted by Fierce Pharma…
Article
Be More Specific: Solving the Specificity Challenge in Metabolomics
Disease processes are complex. Individuals with the same genetic disorder, symptoms, and/or diagnosis can have varied prognosis and response to…
Overview
High Throughput Mass Spectrometry Services for Untargeted Biomarker Profiling
Much like the way next-generation sequencing greatly accelerated discovery of disease-associated genetic variants in the last decade, Sapient next-generation…
Video
Advances in Proteomics & Metabolomics 2022 Online Symposium
Now On Demand | Presented by Technology Networks…
Podcast
SLAS New Matter Podcast: A Conversation on Small Molecule Biomarkers with Dr. Mo Jain
SLAS Scientific Manager Hannah Rosen, PhD is joined by Sapient Founder and CEO Mo Jain, MD, PhD, for an insightful discussion on small…
Webinar
What's Next in Precision Medicine? Small Molecule Biomarkers to Personalize Disease Prediction, Diagnostics and Therapies
Now On Demand | Hosted by AAPS WATCH…
Article
Fierce Pharma Feature: Small molecule biomarkers to align patients, disease, and therapy
Sapient recently contributed a piece to Fierce Pharma discussing the new biological and disease insights that small molecule biomarkers can…
Press Release
University of Oxford Publishes Findings from Its INTERBIO-21st Study Supported by Sapient’s Discovery Metabolomics
September 1, 2022—San Diego, CA—A study led by researchers at the University of Oxford, UK has been published in…
Media
Sapient Featured as Collaborator in Cedars-Sinai Study on Immune Responses and COVID-19
Study infrastructure and biospecimen processing support is being provided by Sapient for the study, which is focused on advancing vital…
Webinar
Mapping the Missing Link: Bridging the Gap Between Human Genetics and Disease Biology Through Small Molecule Biomarker Discovery
Now On Demand | Hosted by AAPS WATCH…
Press Release
Sapient Receives $9.2M Grant for Population-Scale Discovery Mass Spectrometry Analysis
The grant from Bill & Melinda Gates Foundation will support studies to identify biomarkers that can…
Video
Genomic + Small Molecule Biomarkers: for a More Complete Picture of Disease Risk
An individual’s phenotype is not dictated solely by their genetic variants. Environmental factors – where we live, what we…
Media
Sapient Featured in Bruker Press Release Announcing timsTOF Innovations at ASMS 2022
“Sapient’s proprietary, next-generation rapid LC-MS (rLC-MS) technologies leverage the unique bioanalytical capabilities of the Bruker timsTOF Pro 2 system…
Article
Data ≠ Insight: Improving Metabolomics Data Interpretation
Untargeted biomarker discovery aims to uncover previously unknown factors that associate with biologically relevant changes in human health and disease,…
Webinar
Identifying Non-Invasive Biomarkers of Target Engagement
Now On Demand | Hosted by AAPS WATCH…
Article
On the Mark? Identifying Biomarkers of Target Engagement
Retrospective analyses conducted by major pharmaceutical companies on their drug pipelines have revealed that close to…
Infographic
What is Discovery at Scale? Multiplying the Rate of Nontargeted Biomarker Profiling
A drug candidate with an associated biomarker is 2−10x more likely to obtain FDA approval. Why? Because biomarkers help to…
Webinar
Smaller, Faster & More Effective: Clinical Trial Enrichment Using Circulating Biomarkers
Now On Demand | Hosted by AAPS WATCH…
Brochure
Harnessing the Human Microbiome for Discovery
The composition and function of the human gut microbiome are linked to health and disease. Increasing evidence of gut microbes’…
Press Release
Sapient Joins the Foundation for the National Institutes of Health Biomarkers Consortium
San Diego, CA—Sapient, a biomarker discovery organization transforming drug development through rapid, large-scale biomarker profiling, has joined the Foundation for…
Article
Comparison of Omics Techniques and Biomarker Types
High throughput technologies can now capture and measure a huge number of biological molecules within a single human cell or…
Case Study
Discovery of Biomarker to Predict Immunotherapy Related Autoimmunity
Immunotherapy has transformed the treatment of solid organ cancers, rapidly becoming a first line therapy with transformative durable response. While…
Overview
Untargeted Metabolomics Services for an Unprecedented Scale of Biomarker Discovery
Sapient leverages its next-generation mass spectrometry approaches to probe deeper into the human metabolome at a rate is unmatched…
Press Release
Sapient’s Diagnostic Collaboration with Bay Area Lyme Foundation Featured in the Foundation’s Annual Impact Update Report
San Diego, CA—Sapient, a full-service bioanalytical organization transforming drug development through biomarker discovery, has been featured in the Bay Area…
Video
Platform Explainer: How Sapient Accelerates Biomarker Discovery
At Sapient, we believe biomarker-driven drug development can transform lives – and accelerate the process at a fraction of…
Article
Biomarker-Driven Clinical Trials: Enriched with Biology, Evolved for a New Era
Why are large, expensive clinical trials so common? It stems from the challenge of needing to demonstrate treatment efficacy in…
Press Release
Philip Worboys, Ph.D. Joins Sapient as Head of Translational Science
San Diego, CA—Sapient, a full-service bioanalytical research organization transforming the efficiency of biomarker discovery for pharmaceutical and biotechnology sponsors, announced…
Webinar
Large Scale Biomarker Discovery: Next-Gen Mass Spectrometry Profiling to Accelerate Drug Development
Now On Demand | Hosted by AAPS WATCH…
Article
Getting Drug Development Right
The omics revolution has enabled many breakthroughs in our understanding of disease biology, but the productivity of clinical drug development…
Paper
Deep Neural Networks for Classification of LC-MS Spectral Peaks
Nontargeted LC-MS can assay thousands of chemical entities in a single biospecimen, but in that crush of data, how do…
