Now On Demand | Hosted by AAPS
WATCH NOWGenome-wide association studies (GWAS) have been transformative in elucidating the genetic landscape of human disease, defining hundreds of common and rare genetic variants that contribute to the development of disease. The challenge to date, however, lies in understanding the biological mechanisms that underlie these genetic associations and identification of key targets for therapeutic intervention. Circulating small molecule biomarkers provide an opportunity to bridge the gap between large-scale genetics data and biological understanding.
In this session, Dr. Mohit Jain discusses how small molecule biomarkers can provide the missing link between genetics data and high-quality understanding of mechanisms of disease, informing on biological processes linking genetic variants and disease; providing read outs of genetic targeting; and allowing for discovery of new biological targets.

Mapping the Missing Link: Bridging the Gap Between Human Genetics and Disease Biology Through Small Molecule Biomarker Discovery
Now On Demand | Hosted by AAPS WATCH NOW Genome-wide association studies (GWAS) have been transformative in elucidating the genetic landscape of human disease, defining hundreds of common and rare genetic variants that contribute to the development… Read More

Identifying Non-Invasive Biomarkers of Target Engagement
Now On Demand | Hosted by AAPS WATCH NOW A key aspect of the drug discovery pipeline is evaluation of in vivo target engagement and subsequent biological response. While measures of target engagement are often optimized in cellular… Read More

Smaller, Faster & More Effective: Clinical Trial Enrichment Using Circulating Biomarkers
Now On Demand | Hosted by AAPS WATCH NOW Diseases are singularly defined but often represent varied groupings of contributing factors and pathways that ultimately produce a shared pathology. Heterogeneous molecular pathogenesis creates heterogeneity in treatment responsiveness, which… Read More

Large-Scale Mass Spectrometry Profiling: Accelerated Biomarker Discovery to Drive Drug Development
Now On Demand | Hosted by AAPS WATCH NOW Circulating biomarkers are a critical component of the drug discovery process, enabling understanding of complex disease processes, personalization of therapy, evaluation of target engagement, clinical trial optimization, and pharmacometric modeling. Read More