Metabolomics Biomarker Discovery

Nontargeted metabolomics techniques for rapid data generation, data analysis, and validation of small molecule biomarkers

As a provider of bespoke services for the discovery of dynamic biomarkers, Sapient leverages its high throughput, untargeted metabolomics approaches to probe deeper into the human metabolome at a rate is unmatched for discovery. Our mass spectrometry-based methods lead the metabolomics services market in speed and scalability, enabling us to rapidly uncover both known and unknown biomarkers that associate with early disease, disease progression, and drug response.

By pairing nontargeted data generation with advanced metabolomics data analysis, including statistical and pathway analysis, we help identify robust biomarkers to elucidate disease biology, enrich clinical trials, and align patients, disease, and precision therapies. How does it work?

  • Rapid liquid chromatography-mass spectrometry (rLC-MS) – our proprietary systems enable ultra high throughput, population-level metabolomics analysis, capturing and measuring >15K small molecule biomarkers (metabolites and lipids) per sample, in <1 minute analytical cycle time.
  • Biocomputational integration – our expert team of data scientists perform statistical analysis of metabolomics data using machine learning tools to rapidly identify key biomarkers of interest, integrating our spectral data with other high dimensional data from preclinical models, genomics, proteomics, and clinical studies.
  • Human Biology Database – this repository is comprised of spectral data from 100,000+ human biosamples, paired with deep phenotypic information and longitudinal outcomes. Therefore, biomarkers identified through our metabolomics research studies can be cross-validated in large, independent populations.

Learn more about why Sapient is the choice partner for metabolomics biomarker discovery, and how we can work together to advance your drug programs at any phase. Use the sidebar to download our fact sheet or request services directly.

Fact Sheet Download

See how biopharma sponsors are leveraging Sapient’s discovery metabolomics services to accelerate drug development.

Google Ads - Metabolomics - Overview - Fact Sheet Download

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